Generally, a resume is much shorter in length compared to a CV, usually limited to one page. It is meant to be a very brief synopsis of your career and education history. Resumes should focus on measurable accomplishments rather than soft skills or listed responsibilities. Like a CV, resumes need to be updated, but those updates should be made form specific job to which you are applying.
However, this is a case where you’ll want to use your common sense. If you went to college for marketing and had a marketing internship your senior year, then worked as a server for the next several years, you would want to include your marketing internship.