Your goal should be to write your resume with both robots and humans in mind. Many organizations use Applicant Tracking Systems to sort and vet resumes, before hiring managers ever take a look at them. This means that you could have the best experience and qualifications in a whole field of candidates, and a pretty decent resume besides, but your information will fall through the cracks if your resume doesn’t contain the right keywords. Good keywords will refer not only to your experience but to the job description in the posting as well.
Even if you are only sending in copies digitally, it is a good idea to print your resume (as it’s possible that hiring managers may be doing so) to be sure it prints on a single page, and is easy to read in printed form. Reading over a printed copy of your resume will also help you ensure that there is plenty of white space on the page and it looks professional.