However, this is a case where you’ll want to use your common sense. If you went to college for marketing and had a marketing internship your senior year, then worked as a server for the next several years, you would want to include your marketing internship.
If you have major gaps in employment, there are a few ways to make them less noticeable like a change of resume foramt. It is important to be honest about gaps in your resume and not try to cover them up, but to also make them seem productive and intentional. Adding volunteer work or classes in the time you were unemployed is highly valuable and fairly simple to get starter with.