In the short term, you should tweak your resume based on each job you apply to. For example, if one position you’re applying to seems to weigh a certain responsibility or focus over another, you should be sure your resume conveys your expertise in this area. At the same time, you should be updating your resume with your experience as it develops, adding any new skills you’ve learned, courses you’ve taken or awards you won.
Only include your GPA if it is higher than 3.5 on a 4 point scale (no need to mention that 2.0 when you moved into the frat house sophomore year) and only if you are a recent graudate. There are a few exceptions to this rule, like if you’re applying for a job in academia or engineering where a GPA is expected. You can also list honors or awards if you’re a recent graduate. If you attended college, but did not finish your degree, list the number of credits obtained. For recent graduates, education and internship are your main selling point. But if you’ve already been in the workforce, tone down your education section, the best rule of thumb is that one line will suffice.