In the short term, you should tweak your resume based on each job you apply to. For example, if one position you’re applying to seems to weigh a certain responsibility or focus over another, you should be sure your resume conveys your expertise in this area. At the same time, you should be updating your resume with your experience as it develops, adding any new skills you’ve learned, courses you’ve taken or awards you won.
There are some things that don’t belong on a resume for a job. What you exclude is just as important as what you include. Ideally, your resume should reflect experience that is relevant to the job you are applying to, and typically no more than ten to fifteen years in the past. Since your resume should, if possible, be no longer than one or two pages, you may need to nix certain items.